NEPHELE is funded by the Horizon Europe programme under the topic “Future European platforms for the Edge: Meta Operating Systems”. Its vision is to enable the efficient, reliable, and secure end-to-end orchestration of hyper-distributed applications over programmable infrastructure that is spanning across the compute continuum from Cloud-to-Edge-to-IoT, removing existing openness and interoperability barriers in the convergence of IoT technologies against cloud and edge computing orchestration platforms. To this end, NEPHELE introduces automation and decentralized intelligence mechanisms powered by 5G and distributed AI technologies.